PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKCdelta and inactivates the oncogenic isozyme PKCvarepsilon
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چکیده
منابع مشابه
Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides--implications of oxidative protein kinase C regulation to cancer prevention.
We reported previously that cystine produces regulatory responses in purified, recombinant human protein kinase C-delta (PKCdelta) and PKCepsilon via S-thiolation-triggered mechanisms that are consistent with a cancer preventive effect, i.e. stimulation of the pro-apoptotic, tumor-suppressive isozyme PKCdelta and inactivation of the growth-stimulatory, oncogenic isozyme PKCepsilon, at S-cystein...
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From the Departments of Medicine and Pathology, University of California Los Angeles School of Medicine, Los Angeles, California 90024, and the Veterans Administration Center, Los Angeles, California 90073; the Departments of Pediatrics and Internal Medicine, University of Rochester School of Medicine and Strong Memorial Hospital, Rochester, New York 14620; and the Department of Medicine, Dartm...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2003
ISSN: 1460-2180
DOI: 10.1093/carcin/24.2.317